• Automating FAIR, Clean Data Generation from Flow Cytometry at Regeneron

    Bio-IT World | Ronald Realubit, Principal Scientific Business Analyst (Therapeutic Ab Development) at Regeneron, presented a map of the Regeneron team members behind the Automated High-Throughput Flow Cytometry Data Processing Pipeline project, highlighting 38 team members by name. The pipeline was one of three Regeneron projects that won a 2024 Bio-IT World Innovative Practices Award, all sharing the “Informatics to Achieve Operational Excellence” category.

    Jun 6, 2024

  • Precise, Integrated Gene Correction and Integration Offers Therapeutic Benefits

    Bio-IT World | During his keynote address at last month’s PEGS Boston, David Liu, director of the Merkin Institute of Transformative Technologies in Healthcare, vice-chair of the faculty at the Broad Institute of MIT and Harvard, and a Howard Hughes Medical Institute investigator, described how the laboratory evolution of gene editing systems has enabled efficient and programmable gene correction or even whole gene integration.

    Jun 5, 2024

  • Oxford Nanopore’s Clive Brown Looks Back and Ahead

    Bio-IT World | The Oxford Nanopore vision was of a “new generation of single-strand sequencing technology, featuring accurate long reads of single-stranded DNA molecules,” Bio-IT World reported from the 2012 event. Today, Brown’s big ideas include whole-chromosome sequencing, flow cell loading without a pipette, and advances in chemistry, electrical engineering, and commercial format.

    Jun 4, 2024

  • Pan-RAS Inhibitor Offers Hope of Improved Pancreatic Cancer Prognosis

    Bio-IT World | A consortium of pancreatic cancer researchers sharing information in real time has shown that an oral pan-RAS inhibitor known as RMC-7977, developed by Revolution Medicines, effectively targets the common cancer-causing RAS proteins while minimally impacting normal cells—and did so across a comprehensive range of preclinical models in a series of similar experiments.

    May 30, 2024

  • Ambry Genetics, PacBio Take on Rare Diseases, Regeneron Makes TOP500 List, More

    Bio-IT World | Ambry Genetics and PacBio to support the Pediatric Mendelian Genomics Research Center (MGRC) program to better understand the underlying biology of rare diseases; Recursion’s BioHive-2 was dubbed No. 35 on the latest TOP500 list of the world’s fastest supercomputers; the Catalogue of Somatic Mutations in Cancer (COSMIC) launches its 100th version; more.

    May 29, 2024

  • Follow the Money: Funds for Alzheimer’s Research, CN Bio Accelerates Oncology Products, More

    Bio-IT World | Laurence Belfer gifts funds to MD Anderson Cancer Center to strengthen neurodegeneration research through the Belfer Neurodegeneration Consortium; CN Bio plans to accelerate its expanding product portfolio; more.

    May 28, 2024

  • Flagship Pioneering Lessons Learned Launching Biotech Startups

    Bio-IT World | John Damask is a cloud proponent; he makes no apologies for that. And his experience has mostly been with Amazon Web Services; he is clear on that too. With those disclosures out of the way, Damask offered a “Choose Your Own Adventure”-style tour of cloud best practices and the most common startup cloud mistakes at last month’s Bio-IT World Conference & Expo, letting the audience choose the topics he dug into during the talk.

    May 23, 2024

  • Reevaluating Data Platforms: The Future of Decentralized Data

    Bio-IT World | At the 2024 Bio-IT World Conference & Expo, artificial intelligence (AI) was the main topic stirring up discussions and debates, especially generative AI and its data platforms. Data platforms are crucial tools for AI models, yet there are several barriers that hinder their utilization, efficiency, and accessibility —and none of them are technical or data-related.

    May 22, 2024

  • Brain Stimulation Device Could Make Precision Mental Health A Reality

    Bio-IT World | In the not-too-distant future, disorders of the brain could be treated with the same precision as heart disease and cancer. The means will be a therapeutic brain-computer interface (BCI) the size of a small blueberry for people suffering from treatment-resistant depression that uses a similar type of implant technology as Elon Musk’s Neuralink for helping paralyzed people speak.

    May 21, 2024

  • Liquid Biopsy Under Development for Measuring Drug Response

    Bio-IT World | The lab of W. Andy Tao, professor of biochemistry at Purdue University, is pioneering a way to assess drug response based on metabolizing proteins found in circulating extracellular vesicles (EVs), which could serve as a surrogate of their expression level in the liver and become therapeutic targets for some cancers.

    May 16, 2024

  • New Test Looks at Unique Response of MS Patients to Epstein-Barr Virus

    Bio-IT World | Significant evidence now exists implicating the Epstein-Barr virus (EBV) as a causal factor in the development of multiple sclerosis (MS), making treatment of the virus a priority. To that end, research scientists at Trinity College Dublin have developed a blood test to measure the immune response to EBV that could be used as an outcome measure in future clinical trials in people with established MS.

    May 15, 2024

  • AI System For Diagnosing Rare Diseases and Solving Medical Cold Cases

    Bio-IT World | Using an artificial intelligence (AI) model that was trained on millions of variants from identified genetic disorders and incorporates the complex decision-making process of human molecular scientists, investigators at Baylor College of Medicine are on track to automate the diagnosis of an enormous number of undiagnosed conditions.

    May 14, 2024

  • The Replication Crisis: How Can Open Science Improve the Scale of Reproducibility?

    Bio-IT World | For years, two of the key principles of science have been replication and the ability to produce consistent results. Yet, scientists across fields today are still grappling with challenges in ensuring the repeatability and reliability of their findings. More recently, this has been referred to as the ‘replication crisis’ or ‘reproducibility crisis’ and details the growing concerns around the lack of reproducibility in scientific studies.

    May 10, 2024

  • Digital Twin of Infant Microbiome Reliably Predicts Cognitive Deficits

    Bio-IT World | Researchers at the University of Chicago have succeeded in creating a digital twin of the gut microbiome of premature infants that reliably models the many interactions taking place between quickly changing bacterial inhabitants. The so-called “Q-net” model, created with generative artificial intelligence (AI), was used to make predictions about which infants were going to have neurodevelopmental deficits using head circumference as the proxy.

    May 8, 2024

  • Hype and Disruption: Post-Dagdigian Trends Talk Splits in Two

    Bio-IT World | It finally happened. After being absent from last year’s “Trends from the Trenches” talk at the Bio-IT World Conference & Expo, BioTeam cofounder Chris Dagdigian has officially retired from delivering the traditional conference-closer.

    May 7, 2024

  • Digital Twins in an Expansive Future

    Bio-IT World | The practice of medicine has struggled to adopt data-driven tools, Dr. Caroline Chung told the audience at last month’s Bio-IT World Conference & Expo. Even when tools are developed, getting them into clinical practice has been slow.

    May 2, 2024

  • Novel Diagnostic System Finds Role of Immune System in Alzheimer’s Disease

    Bio-IT World | Researchers in Denmark have devised a blood-based diagnostic technique that can detect even trace amounts of an aggregated protein indicative of Alzheimer’s disease before any disease-related changes show up on a PET scan, one of the traditional testing methods.

    May 1, 2024

  • Arena Bioworks: Changing the Incentive Model for Biomedical Research

    Bio-IT World | Last week, Steve Pagliuca was flying to Milan to catch an Atalanta football match, an Italian professional football club of which he is part owner. But before his flight, he stopped to talk biotech at the Bio-IT World Venture, Innovation & Partnering Conference held in conjunction with the Bio-IT World Conference & Expo.

    Apr 30, 2024

  • Ginkgo Bioworks, Novo Nordisk Partnership, Mission Bio Updates Platform, PathAI, Google Cloud Team Up, More

    Bio-IT World | Ginkgo Bioworks has expanded its strategic partnership with Novo Nordisk; Mission Bio introduced sample multiplexing features for the company’s Tapestri Platform; PathAI announced a strategic partnership with Google Cloud at Bio-IT World Conference & Expo to help biopharma companies and anatomic pathology labs accelerate the adoption of AI and digital pathology; more.

    Apr 25, 2024

  • Follow the Money: Lymphatic System Platform, Endovascular Device System, Generative AI For Small Molecule Therapies, More

    Bio-IT World | Seaport Therapeutics plans to advance their Glyph platform, which leverages the lymphatic system to create new medicines building on clinically validated mechanisms and has demonstrated clinical proof-of-concept; Nectero Medical will accelerate the execution of the Phase II/III (stAAAble) trial and to support the submission of a New Drug Application with the U.S. Food and Drug Administration for the Nectero Endovascular Aneurysm Stabilization Treatment (Nectero EAST) System; DeepCure will further develop its generative AI and physics-based engine to innovate the discovery of small molecule therapies for challenging targets; more.

    Apr 24, 2024