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A 1970s Lipid-Lowering Compound May Offer a New Approach to Obesity
Sep 16 | Bio-IT World | Obesity can cause metabolic conditions, including abnormal blood lipid levels, insulin resistance, and diabetes. New research from Science Advances has identified a potential therapeutic candidate for obesity that boosts the body’s metabolic rate: 5-tetradecyloxy-2-furoic acid or TOFA More -
Lehigh Team Uses Digital Twin of Gut-Brain Axis to Advance Neurostimulation Therapies
Sep 15 | Bio-IT World | AI is reshaping pharmaceutical manufacturing. We see it being used to automate tasks, uncover insights, and optimize quality. By analyzing complex, rich datasets, AI can predict deviations, fine-tune processes, and accelerate routine tasks and documentation, leading to faster production and higher-quality outcomes. Good Manufacturing Practice environments are precise, traceable, and controlled. Yet as operations scale and complexity grow, maintaining GMP standards is increasingly difficult. This is where AI excels. More -
What It Takes to Make Generative AI Fit for GMP
Sep 11 | Bio-IT World | AI is reshaping pharmaceutical manufacturing. We see it being used to automate tasks, uncover insights, and optimize quality. By analyzing complex, rich datasets, AI can predict deviations, fine-tune processes, and accelerate routine tasks and documentation, leading to faster production and higher-quality outcomes. Good Manufacturing Practice environments are precise, traceable, and controlled. Yet as operations scale and complexity grow, maintaining GMP standards is increasingly difficult. This is where AI excels. More -
Ultima, NVIDIA, Google Partner on Pangenome-Aware Whole Genome Sequencing
Sep 09 | Bio-IT World | Ultima Genomics and NVIDIA are collaborating to enable pangenome-aware whole genome sequencing (WGS) analysis, combining Ultima’s high-output, cost-efficient sequencing platform with accelerated GPU-enhanced computational approaches from NVIDIA and Google’s open source DeepVariant for pangenome graph alignment and variant calling. The collaboration aims to make pangenome-aware WGS variant calling practical. More -
Clearing the Bench-To-Bedside Hurdle: Why Translational Medicine Needs to Start Earlier
Sep 04 | Bio-IT World | There’s an enormous graveyard for medical innovations that showed tremendous promise in the lab yet stalled out in early clinical trials and never reached patients at scale. We've largely come to accept this high failure rate as an inevitable reality of translational medicine. But over the past 17 years developing an implantable ultrasound platform for blood-brain barrier modulation, I've come to a different conclusion: we're asking translational medicine to solve problems that should have been addressed much earlier in development. More -
NVIDIA Acquires Hugging Face for $12.93 Billion
Sep 03 | Bio-IT World This morning NVIDIA announced its agreement to acquire Hugging Face for $12.93 billion. The two groups plan to scale Hugging Face’s platform, strengthen its infrastructure and expand access to AI for developers and institutions worldwide. More -
Deep-Learning Tool Uses Long-Read Sequencing to Detect Cancer Mutations
Sep 02 | Bio-IT World | Analyzing genetic changes in cancer cells can provide insight into how tumors develop and inform precision oncology. However, identifying cancer-related mutations can be challenging, particularly when they occur at low frequencies or in complex regions of the genome. Researchers at The University of Hong Kong have developed ClairS, a tool designed to detect small cancer-related genetic mutations from long-read sequencing data. More -
Trends from the Trenches: Rethinking Computational Workflows for Modern Genomics
Sep 01 | Bio-IT World | Modern genomics and precision medicine are generating data at a scale that is challenging traditional bioinformatics workflows. As researchers increasingly combine genomic data with phenotype, transcriptomics, proteomics, and imaging, they face growing demands for reproducible pipelines, standardized methods, and collaboration across laboratories, hospitals, and biobanks. In the latest episode of Trends from the Trenches, Ben Busby, global alliance manager for omics at NVIDIA, argues that addressing those challenges requires a shift in how scientists approach computational research. More -
What Scientists Actually Need From AI
Aug 28 | Bio-IT World | A target looks good on paper. The literature supports it, the mechanism is plausible, and three independent groups have published findings that point the same direction. There is also a contradictory result, which someone found early, mentioned in a meeting, and set aside because it seemed less persuasive than the rest. The team builds its case, and the program advances. Years later, in preclinical validation or, worse, in the clinic, that discarded finding turns out to have been the important one. More -
Follow the Money: Biological Foundation Models, Automated Bioanalysis, Predictive Cancer Care
Aug 26 | Bio-IT World | LifeMine Therapeutics advances a novel treatment for organ transplantation; InduPro doses the first patient in a phase 1 study of a bispecific antibody-drug conjugate; Remepy advances an AI-enabled treatment for Parkinson’s disease; and more. More
Corning’s MSCulture Max media increases final hMSC yields, streamlines culture, reduces in-process risk, and eliminates media exchanges, enabling higher cell expansion with less media and fewer media changes. The MSCulture Max media consists of a basal medium and supplement with 3 versions available:
- Standard research-grade medium for MSC expansion
- Xeno-free medium optimized for rapid MSC expansion
- Xeno-free GMP-grade medium for bioproduction
Bio-IT World’s Trends from the Trenches podcast delivers your insider’s look at the science, technology, and executive trends driving the life sciences through conversations with industry leaders. BioTeam co-founder Stan Gloss brings years of industry experience in science, data, and technology to conversations exploring what is driving data and discovery, and what’s coming next.
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