• How Paratope Refinement Can Mitigate Antibody Polyspecificity

    Bio-IT World | There is often a lack of understanding in drug discovery about how polyspecificity drives antibody toxicity. This shows polyspecificity is an underappreciated phenomenon in therapeutic antibody development, but that these unwanted properties can be fully improved by paratope refinement.

    Jul 3, 2019

  • MELLODDY Using Federated Learning To Improve Drug Development

    Bio-IT World | A 17-partner consortium in Europe is seeking to confirm the utility of a machine learning platform for better predicting promising compounds for drug development. The three-year initiative, which launched in June, represents the first large-scale deployment of blockchain technology to extract insights from multiple preclinical datasets without having to first pool the data.

    Jul 2, 2019

  • LabTwin, AbCellera, X4, And More: News From June 2019

    Bio-IT World | June featured exciting new, products, and partnerships from around the bio-IT community from innovating companies, organizations, and universities, including LabTwin, AbCellera, X4, and more.

    Jul 1, 2019

  • The RGC UK Biobank Consortium Data Delivery And Cohort Browser

    Bio-IT World | The Regeneron Genetics Center has undertaken the exome sequencing and analysis of 500,000 samples from the UK Biobank, using the DNAnexus Platform to host the dataset and run Regeneron’s software pipeline. To increase the value to the RGC UKB consortium, Regeneron and DNAnexus partnered to construct a combined database of the UKB genomic and phenotypic data to explore through an innovative user interface.

    Jun 28, 2019

  • AbbVie, Discngine Collaborate On Structure-Based Drug Discovery Explorer

    Bio-IT World | Although wildly used, rational structure-based drug design techniques are far from being applied to their fullest potential. AbbVie and Discngine addressed the pitfalls by co-developing a web-based structural knowledge management solution called 3decision.

    Jun 26, 2019

  • Sentieon's 'Faster/Cheaper' Genomics Tools

    Bio-IT World | Sentieon's DNAseq and TNseq software, are making waves in the life sciences, creating a "drop in replacement" that is a faster and cheaper alternative to the industry standard for secondary analysis in next-generation sequencing (NGS) data processing while producing the industry standard results.

    Jun 25, 2019

  • Tracking The Clinical And Preclinical Progress In Targeting Membrane Proteins

    Bio-IT World | G protein-coupled receptors (GPCRs), ion channels, and transporters represent some of the most important drug target classes across a wide range of diseases. According to Catherine Hutchings, progress in targeting these membrane proteins requires a recognition of not only what works, but also what doesn't.

    Jun 24, 2019

  • Officials Say They Lack Authority To Halt CRISPR Babies Plan In Russia

    STAT | Two influential leaders in science for the first time publicly condemned a Russian biologist who said he plans to produce gene-edited babies but conceded that it was beyond their organizations’ authority to halt him from doing so.

    Jun 24, 2019

  • High-Confidence Characterization Of Small Molecule 'Unknowns': How Software Is Enabling Intelligent, High-Resolution Accurate Mass LC-MS/MS Data Acquisition

    Bio-IT World Contributed Commentary | Liquid chromatography-tandem mass spectrometry has proven to be a powerful tool for small molecule analysis. However, the identification of so-called "unknown-unknowns" is extremely challenging.

    Jun 17, 2019

  • Deep Genomics Identifies Rare Disease Targets Using AI System

    Bio-IT World News Brief | Deep Genomics' AI system has identified 1,600 rare disease targets that can be drugged using its splice-switching oligonucleotide technology.

    Jun 14, 2019

  • Biobanking: A Thing Of The Past?

    Bio-IT World | Andrew Brooks, COO at RUCDR Infinite Biologics and Professor of Genetics at Rutgers University, discusses the changes he's seen in biobanking over the last decade, including the rapid changes direct to consumer applications are bringing to research biobanks, and whether or not traditional biobanks are a thing of the past.

    Jun 13, 2019

  • Golden Helix Releases Cancer Add-On To VSClinical

    Bio-IT World News Brief | Golden Helix has announced a cancer addition to their clinical analytics product, VSClinical. This new capability will guide clinicians through the clinical assessment of somatic variants, adding workflows modeled off the guidelines issued by the Association of Molecular Pathologists.

    Jun 10, 2019

  • Organoids And Their Impact On Pre-Clinical Drug Discovery

    Bio-IT World | Pharmaceutical companies are looking for ways to save time and money in the drug discovery process. If there was a way to determine a therapy's impact in the pre-clinical process, researchers would have a better understanding of where to focus their efforts. This is where organoids come in.

    Jun 7, 2019

  • The Future Of Blockchain: The Use Cases Set To Reshape Life Sciences

    Bio-IT World Contributed Commentary | Ever since blockchain burst onto the scene a decade ago, people have continually found new—and sometimes odd—applications for the technology. Yet when it comes to the life sciences, a lack of practical applications has resulted in blockchain being considered a "hammer in search of a nail."

    Jun 5, 2019

  • 2 Chinese Babies With Edited Genes May Face Higher Risk Of Premature Death

    NPR.org | There are new concerns about the world's first genetically modified babies. It appears that the genetic variation a Chinese scientist was trying to recreate when he edited twin girls' DNA may be more harmful than helpful to health overall, according to a study published Monday.

    Jun 3, 2019

  • PerkinElmer Joins Accenture's Open Partner Ecosystem

    Bio-IT World | PerkinElmer has signed on to Accenture's open partner ecosystem and will integrate its big data technology and content into the cloud-based platform's wider efforts in drug discovery and research.

    Jun 3, 2019

  • Grail Outlines Its Plans For A Blood Test To Detect Cancer

    STAT | Could a blood test detect cancer in healthy people? Grail, a Menlo Park, Calif.-based company, has raised $1.6 billion in venture capital to prove the answer is yes.

    May 31, 2019

  • ACD/Labs, Genomenon, Accenture, And More: News From May 2019

    Bio-IT World | May featured exciting new, products, and partnerships from around the bio-IT community from innovating companies, organizations, and universities, including ACD/Labs, Genomenon, Accenture, and more.

    May 30, 2019

  • MGI Sues Illumina for Patent Infringement in the United States

    Bio-IT World News Brief | Complete Genomics Inc., a US subsidiary of MGI, has filed a patent infringement lawsuit against Illumina in US District Court for the District of Delaware.

    May 29, 2019

  • Exploring The Species Near Us

    Bio-IT World | Rob Dunn, Professor of Applied Ecology, North Carolina State University has written an engaging and absorbing account of his adventures in ecology, starting with field work in the remote rain forests of Costa Rica. Eventually he learned he could discover closer to home—and help students identify—previously unknown bacteria and insects in houses, including those living in showerheads and extremophiles living in freezers and ovens.

    May 23, 2019