• Protein-Metabolite Interactome Is Vast Untapped Frontier For Drug Discovery

    Bio-IT World | Researchers at the University of Utah have created a systematic approach to reveal the endogenous protein-metabolite interactome at high-throughput speed. The platform quickly identifies metabolites that putatively interact with target proteins.

    Apr 13, 2023

  • AI-Based Retinal Aging Clock Gauges Effectiveness Of Anti-Aging Interventions

    Bio-IT World | Retinal scans offer a fascinating window into the health of the body’s circulatory system and brain functioning as well as identify eye diseases that aren't visibly noticeable. Now, a new study suggests that this artificial intelligence-based technology is also good for predicting how well people are aging.

    Apr 11, 2023

  • For Success in Lab Automation, Bridge the Gap Between Science and IT

    Bio-IT World | When implementing laboratory automation, one of the biggest challenges can be group dynamics: getting scientific and IT teams on the same page. Both groups are integral to the success of an automated setup, but often they have very different perspectives and might even be resistant to working together. It’s important to understand why so that we can overcome this issue.

    Apr 7, 2023

  • Global Collaboration Enables Headway On Rare Neuroendocrine Tumors

    Bio-IT World | Researchers in Madrid recently wrapped up the largest-yet genomic study of rare neuroendocrine tumors, known as pheochromocytomas and paragangliomas, which identified a seemingly perfect panel of metastatic disease markers as well as a group of patients who could potentially benefit from immunotherapy. The objective here is a better means to predict, at the time of diagnosis of the primary tumor, whether patients will be immediately affected by cancer spread.

    Apr 6, 2023

  • ‘AMAR’ Is Latest Addition To The List Of Anti-Aging Hopefuls

    Bio-IT World | Using “genetic trickery,” scientists at the University of Virginia (UVA) have hit on a means to detoxify the body of fat byproducts and, with that, extend the healthy lifespan of the model organism C. Elegans. The specific trick was to boost the activity of two enzymes involved in alcohol detoxification.

    Apr 4, 2023

  • Johns Hopkins, NASA to Send Human Heart ‘Tissue-on-a-Chip’ Into Space, New Adverse Event Detection Product Aids Pharmacovigilance Surveillance, More

    Bio-IT World | A proprietary deep learning platform that identifies novel molecules through protein-ligand co-folding; PacBio’s long-read sequencing systems help researchers scale their interrogation of the full genome; a cardiovascular disease detection platform that combines the latest advancements in applied machine learning with one of the most ubiquitous medical devices in the world: the stethoscope; and more.

    Mar 30, 2023

  • Illumina Releases International Version of Tertiary Clinical NGS Analysis Software

    Bio-IT World | Illumina has released Connected Insights, a cloud-based software for tertiary analysis for clinical next-generation sequencing (NGS) data. The software is commercially available in a limited number of countries and in beta testing in the US.

    Mar 29, 2023

  • Genome Citation Service Tracks Genomes Across Research

    Bio-IT World | Kjiersten Fagnan, chief informatics officer at Lawrence Berkeley National Laboratory’s Joint Genome Institute appears on the Trends from the Trenches podcast to speak with host Stan Gloss of BioTeam about the JGI’s Genome Citation Service, a new offering that connects the broader community with the organization’s data resources and infrastructure.

    Mar 28, 2023

  • Follow the Money: Recombinase Platform Unlocks Full Potential of Gene Editing, Lead Drug Candidate Clears Neurodegenerative Toxins, More

    Bio-IT World | Funding pipeline advancement of first-in-class extracellular protein degraders, a proteomics AI-based platform that comprehensively maps the course of a disease, a proprietary computational antibody drug discovery platform that uses machine learning to model antibody-antigen interactions, and more.

    Mar 28, 2023

  • PacBio Releases Computational Tool for Parsing Pseudogenes

    Bio-IT World | PacBio last week announced a new informatics method that genotypes gene paralogs and pseudogenes with high accuracy. The computational tool, named Paraphase, enables variant calling, copy number analysis and phasing by identifying the full gene sequence of each of the haplotypes for all genes and pseudogenes of the same gene family.

    Mar 24, 2023

  • Neighborhood Analysis Highlights Role Of Macrophages In ER+ Breast Cancers

    Bio-IT World | When it comes to breast cancer, the most commonly occurring estrogen receptor-positive (ER+) variety is a poor candidate for treatment with conventional immunotherapies designed to help the patient’s own immune system fight back. Unlike triple-negative breast cancer, ER+ tumors don’t have many infiltrating T cells so potentiating their function alone doesn’t make much of a difference.

    Mar 22, 2023

  • Japanese Medical Team Discovers Gut Microbiota to Diagnose and Treat Dementia with Lewy Bodies

    Bio-IT World | A research team from the Nagoya University Graduate School of Medicine, Japan, discovered three gut bacteria types that may lead to predicting and treating dementia with Lewy bodies.

    Mar 21, 2023

  • Current Microbiome Analyses Turning Up High Number Of False-Positives

    Bio-IT World | Insufficient taxonomic information in public sequence records is a longstanding problem that was again brought to light in a recent study of simulated microbial communities. Researchers in Spain, using standard techniques to explore virtual microbiome communities, found that results obtained from DNA analyses bear little resemblance to the real-world bacterial populations being imitated and many of the detected species are not actually present.

    Mar 16, 2023

  • Marker Discovered Signaling Squamous Cell Skin Cancer About To Spread

    Bio-IT World | Researchers have found that dyskerin, a protein that provides stability to non-coding small nucleolar RNAs, signals when cutaneous squamous cell carcinomas are preparing to metastasize by migrating to the lymph nodes. Because these cancer cells temporarily stop consuming glucose and instead feed on low-density lipoprotein cholesterol molecules, the new marker may be a promising candidate for treatments involving lipid metabolism inhibitors.

    Mar 15, 2023

  • Spatial Biology Poised for Explosion by 2027

    Bio-IT World | Spatial biology is poised for an explosion in the next few years, said Colin Enderlein, a principle at DeciBio Consulting. Speaking in San Diego at the Molecular and Precision Med Tri-Con, Enderlein shared the results of DeciBio’s recent market report on the space.

    Mar 14, 2023

  • Craig Venter on Genomics’ Past and Precision Medicine’s Future

    Bio-IT World | Kevin Davies and Craig Venter sat down together to celebrate thirty years of the Molecular and Precision Med Tri-Con this week in San Diego on Monday night. Davies—the founding editor of Bio-IT World—gave a guided tour of human genomic research and sequencing since 1991 with Venter offering first person color commentary along the way.

    Mar 9, 2023

  • New Telomere Measuring Method Addressing Limitations Of Current Options

    Bio-IT World | A research collaboration led by led by Duke-NUS Medical School and National Heart Centre Singapore has set the stage for telomere measurement to one day be added to the list of clinical-grade methods for assessing biological aging. The focus is on rapid and precise measurement of individual telomeres using a technique that employs “telobaits” that latch onto the ends of telomeres in large pools of DNA fragments.

    Mar 8, 2023

  • Pharma-Diagnostics Lockstep: How Two Industries Can Work Together for Precision Medicine

    Bio-IT World | Sarah Hersey, VP of Precision Medicine at Bristol Myers Squibb, gave a balanced view of the challenges and opportunities facing precision medicine in her keynote address at the Molecular & Precision Medicine Tri-Conference in San Diego this week. After her presentation she was joined by others in the space to talk about the future for diagnostics and precision medicine.

    Mar 7, 2023

  • Therapeutic Targets For MS Found In The Gut

    Bio-IT World | Neuroscientists at the University of Virginia have succeeded in alleviating the harmful inflammation of multiple sclerosis in a mouse model of the disease by modulating the gut microbiome to disable a key immune regulator known as aryl hydrocarbon receptor.

    Mar 2, 2023

  • Forged in Steel, Exscientia Brings New Processes to Drug Development

    Bio-IT World | Andrew Hopkins, CEO and Executive Director of Exscientia, speaks with host Stan Gloss of BioTeam about Exscientia’s machine learning-based and model-driven approach to drug design, the connection between knowledge and efficiency in drug optimization projects, and its fourth platform-designed drug launch into the clinic.

    Feb 28, 2023