Creative Biostructure Performs Comprehensive Lead Discovery and Optimization Solutions

Creative Biostructure, a biotech company specialized in providing cost-effective contract services related to structural biology and membrane protein technologies to both academia and biotech industries, now applies its expertise in structural biology and membrane proteins to the drug discovery process for structure accelerated drug discovery.

Now, Creative Biostructure performs comprehensive lead discovery and optimization solutions including library construction, library screening (in silico, in vitro and in vivo), hit-to-lead optimization and preclinical evaluation, etc. to customers all over the world.

Lead discovery and optimization plays a crucial role to determine the quality of clinical candidates. After this process, a set of compounds can be screened that interact with the target and the confirmed hits have specific activity against the target. Modern drug discovery involves identifying screening hits, medicinal chemistry, and optimizing these hits to increase affinity, selectivity, efficacy/efficacy, metabolic stability, and oral bioavailability.

Three approaches are utilized at Creative Biostructure for lead discovery: high-throughput screening, virtual screening and fragment-based drug discovery. Besides, Creative Biostructure supports the discovery of leads from existing leads/drugs and natural products.

For lead optimization, several approaches are taken to improve potency, selectivity, physicochemical and pharmacological properties of the lead compounds. Highly responsive team at Creative Biostructure consists of interdisciplinary scientists and experts in chemistry, structural and computational biology, drug design, biochemistry, molecular biology and cell biology.

Services at Creative Biostructure mainly include:

Hit identification

Hit to Lead

Lead optimization and preclinical development

Natural product identification and production

“With over 10 years of experience in the field of structural biology, and drug discovery projects targeting GPCR, kinases, phosphatases and epigenetic proteins, and customized drug discovery strategies to identify lead compounds and preclinical drug candidates according to specific demands of customers, we are determined to help customers accelerate their drug discovery process, helping improving people’s life through life technology.” Commented the chief marketing staff at Creative Biostructure.

If you want to know more detailed information about the lead discovery and optimization solutions provided by Creative Biostructure, please visit https://drug-discovery.creative-biostructure.com/lead-discovery-and-optimization-p19.