Peptide Library and Peptide Array Released by Creative Peptides: Useful Tools for Protein-Protein Interaction Research

NEW YORK, NY, UNITED STATES - Sep 19, 2019 - As one of the world's leading peptide suppliers, the New York-based company Creative Peptides announced the release of peptide library and peptide array, providing powerful tools for scientists who are involved with protein-protein interaction research, drug R&D and many other possible applications associated with biochemicals and pharmaceuticals.

Compound screening using libraries and arrays is a well-established practice. The composing elements of arrays and libraries, including small organic compounds, DNA, proteins and peptides, can be accommodated to specific needs as required in different projects. This high-throughput method primarily aims for detecting and exploring relationship between structure and function for proteins. Among its various applications, the most commonly seen include protein-protein interactions, carbohydrate arrays, epitope mapping, and enzyme binding.

"Usually, the peptides in a peptide library is of large quantities and all of them are composed of systematic combinations of amino acids. That is to say, these peptides might be of the same length and contain the same amino acid components, which are combined in different sequences," says Dr. Robert Martinez, spokesperson from Creative Peptides. "The reason for the popularity of peptide library is that scientists need to map the precise binding sites in characterizing protein-protein interactions, so as to gain a better understanding of cell functionality.”

Peptide array libraries usually contain partly overlapping peptides, which are derived from the sequence of one protein coming from the complex to be studied. Scientists can attach theses overlapping peptides to a solid support using a wide range of techniques like SPOT-synthesis and photolithography. After that, the array is incubated with the partner protein from the complex of interest. The last step is to detect the protein-bound peptides using immunodetection assays. All these studies are helpful in improving our fundamental understanding of cellular processes. Moreover, the relevant research findings can then serve as a basis for the design of drugs that inhibit or activate the target protein-protein interactions.

“In terms of techniques used to create peptide libraries, the most widely adopted are solid-phase peptide synthesis and phage display. After years of efforts in peptide library design, up till now we have established wide varieties of peptide libraries, which are intended for separating minimal length active peptide sequences, for identifying critical amino acid residues, and for designing sequence-optimized analogs, etc.” further explains Dr. Martinez.

Below listed are some of the peptide libraries and arrays available at Creative Peptides:

• Overlapping Peptide Libraries
• Truncation Peptide Libraries
• Alanine Scanning Library
• Positional Scanning Library
• Scrambled Library
• Peptide Microarray

For protease and kinase studies, peptide microarrays are supplied as well. To know more about the peptide libraries and arrays at Creative Peptides, please visit: https://www.creative-peptides.com/services/peptide-library-and-array.html.

About Creative Peptides

As a seasoned enterprise in the biopharmaceutical industry, Creative Peptides has already gained a fame as a vendor in supplying therapeutic peptides, amino acids, cosmetic peptides, catalog peptides, fluorescent labeling reagents as well as nucleotides and nucleosides. Besides, the expertise of its high-caliber scientists also allow the conducting of various integrated peptide services, covering GMP manufacturing, peptide drug discovery, long peptides synthesis, oligopeptide synthesis, peptide analysis, peptide lead optimization and many more.