Screening Compound Libraries from Otava

TORONTO, CANADA - Sep 25, 2014 - Chemical libraries for a long time have been a cornerstone in the search for new pharmaceutical compounds. They have been created using many different paradigms. In order to find appropriate effects on target proteins diverse collections of unique compounds have been screened. Such large libraries continue to be used for drug discovery, but screening focused libraries, can provide more efficient solutions with better rates.

Focused compound libraries are the collections of compounds with in silico predicted high affinity to the target protein. In order to design and compose focused libraries we apply modern methods of medicinal chemistry. Our proprietary method for receptor-based virtual screening of compounds includes powerful combination of drug-likeness filtering, molecular docking, re-scoring, key intermolecular hydrogen bond detection and, finally, visual inspection of ligand-receptor complexes. OTAVA discovery collection includes various focused libraries.

In the design of protein families libraries OTAVA focuses its attention on the most interesting research areas. This set of libraries with a variety of novel compounds is an excellent starting point for research chemists and biologists in drug discovery.

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