Biopharma PEG Supplies Multi-arm PEG Derivatives Crosslinked Into Hydrogels

Polyethylene glycol (PEG) is the polymer with the lowest level of absorption by proteins and cells among known polymers so far. PEG is easily soluble in water, ethanol and most common solvents at room temperature, and is non-toxic, harmless and non-irritating to the human body , commonly used in the pharmaceutical industry with various drugs. With good biocompatibility, lubricity, and moisturizing properties, polyethylene glycol is widely used in various industries and can be seen everywhere in daily life.

In addition to being used in drugs, PEG materials can also be used in medical devices that assist tissue regeneration and wound healing, mainly due to their excellent solubility, good biocompatibility, non-toxicity and low immunogenicity. In medical devices, PEG derivatives are mainly multi-arm structures, which can form hydrogels due to their relatively large molecular weight. After spraying this hydrogel on the wound site, the hydrogels quickly solidify to prevent wound bleeding and infection, and degrades on its own after the wound has healed. At the same time, spraying this hydrogel onto the organ surface can effectively prevent the adhesion of internal organs during surgery and lead to disease aggravation.

Biopharma PEG is a company specializing in the research, development, production and sales of polyethylene glycol and its active derivatives. “Our multi-arm PEG derivatives can be cross-linked into hydrogels. In response to current hydrogel needs, we can provide bulk orders for 4 kinds of 4-arm PEG products with high purity that used in hydrogels, offering the opportunity to match customers' special quality requirements”, said the chief chemist of Biopharma PEG,

Injectable hydrogels have been widely used in bone tissue engineering due to their good physicochemical properties, good biocompatibility, and structural similarity to extracellular matrix. However, injectable hydrogels often exhibit poor mechanical strength. The drug delivery performance of most injectable hydrogels is also poor because of their limited penetration ability and inability to incorporate many therapeutic drugs, especially small molecule drugs and bioactive ions. Therefore, developing an injectable hydrogel with good mechanical strength and effective drug loading remains a major challenge.

Chitosan (CS)/glycerophosphate (GP)-based injectable hydrogels are highly heat-sensitive and have been commercialized in wound-healing applications. But its mechanical properties are weak. Multi-arm crosslinkers based on polyethylene glycol (PEG) can assemble polymer chains into interwoven networks due to their active functional groups, enabling hydrogels to have adjustable mechanical properties and controllable preparation methods. Functional proteins and other biomolecules can be introduced into hydrogels through 4-arm PEG, so they can be used in the construction of hydrogels and improve the mechanical properties of hydrogels.

Biopharma PEG is a company specializing in the research, development, production and sales of polyethylene glycol and its active derivatives. We provide high-purity multi-arm PEG products, such as 4-ArmPEG-SG, 4-ArmPEG-SS, 8-ArmPEG-SG, 8-ArmPEG-SS for use in hydrogels. We have a large amount of stock, and can also provide the quantity from g to kg according to the needs of customers.

Biochempeg provides high quality activated multi-arm polyethylene glycol derivatives (PEGs) with high purity and low polydispersity. Biochempeg's multi-arm PEG derivatives can be cross-linked into hydrogels. Biochempeg provides GMP grade PEG derivatives and bulk orders via custom synthesis, offering the opportunity to match customers' special quality requirements.