IntegrateRNA Develops Premade Circular RNA Products to Satisfy Various Downstream Applications

IntegrateRNA, the division of Creative Biogene, has gradually become one of the best partners for various types of RNA discovery, analysis, and related bioinformatics services. Relying on precise and efficient RNA synthesis technology, IntegrateRNA is dedicated to providing customers with customized RNA fragments to meet different needs, altering the way to disease treatment, whether as a drug or a therapeutic target. Recently, IntegrateRNA announced the release of a series of premade circular RNA products to satisfy various downstream applications.

CircRNAs are more stable than their linear mRNA counterparts, and the median half-life of circRNAs in mammalian cells is at least 2.5-fold longer than that of their linear mRNA isoforms. For this reason, circular RNAs (circRNAs) are highly stable RNA molecules that are attractive templates for the expression of therapeutic proteins and noncoding RNAs. Therefore, circRNAs are ideal platforms for next-generation mRNA therapeutics.

EGFP circRNA will express an enhanced version of green fluorescent protein, which was originally isolated from the jellyfish Aequorea victoria. The fluorescence of EGFP protein can be easily detected by fluorescence microscopy or flow cytometry. Therefore, EGFP circRNA is ideal for monitoring and optimizing transfection efficiency and is recommended as a positive control for circular RNA transfection.

Firefly Luciferase circRNA will express a luciferase protein originally isolated from the firefly Photinus pyralis. It emits bioluminescence in the presence of the substrate luciferin. Therefore, firefly luciferase circRNA is ideal for monitoring and optimizing transfection efficiency and is recommended as a positive control for circular RNA transfection.

Gaussia luciferase circRNA will express a luciferase protein derived from Gaussiaprinceps. It emits bioluminescence in the presence of the substrate luciferin. Therefore, Gaussia Luciferase circRNA is ideal for monitoring and optimizing transfection efficiency and is recommended as a positive control for circular RNA transfection.

Renilla Luciferase circRNA will express a bioluminescent reporter protein from Renilla reniformis. Therefore, Renilla luciferase circRNA is ideal for monitoring and optimizing transfection efficiency and is recommended as a positive control for circular RNA transfection.

mCherry circRNA will express a red fluorescent protein derived from Discosoma sp. The fluorescence of mCherry proteins can be easily detected by fluorescence microscopy or flow cytometry. Therefore, mCherry circRNA is ideal for monitoring and optimizing transfection efficiency and is recommended as a positive control for circular RNA transfection.

“We have successfully performed many different types of RNA discovery, synthesis, functional studies, and bioinformatics analysis, including circRNAs, lncRNAs, mRNAs, and more.” said Marcia Brady, the marketing director of Creative Biogene, she also claimed, “Our team is capable to develop customized solutions for any specific requirements.”

About IntegrateRNA

IntegrateRNA, as the division of Creative Biogene that holds a leading position in providing complete solutions for RNA research, has years of experience in next-generation sequencing and develops microarray platforms that enable researchers to explore the world of RNA on an unprecedented scale, and mapping all RNAs involved in cell life programs, human diseases, and drug discovery.