Creative Peptides Rolls Out PNA FISH Probes with High Sensitivity and Specific Hybridization

New York, United States - March 15, 2022—Creative Peptides, as a pioneering biomedical technology company in the United States, is qualified to provide highly specific products and services for life science research. To promote PNA biology research, Creative Peptides offers various PNA FISH probes such as telomere probes and CAG repeat probes.

Fluorescence in situ hybridization (FISH) is a cytogenetic method to detect and target the presence or absence of specific DNA sequences on chromosomes. Peptide nucleic acid (PNA) is a synthetic polymer similar to DNA or RNA. Its high binding strength and great specific hybridization add scientific appeal to researchers. And the probes, which can be RNA, DNA, or oligonucleotide sequence, are applied to detect the expression of a specific gene or transcription product.

PNA probes are widely used in the fields of genetically modified testing, microbial and Yersinia pestis detection, as well as disease diagnosis. Creative Peptides developed different PNA probes targeted to specific research purposes. For instance, telomere PNA probes can conduct qualitative and quantitative analyses of repeated telomere sequences. Centromeric PNA probes can identify the centromeric region of each chromosome and detect the numerical analyses of chromosomes. Therefore, it’s convenient for clients to choose the probe products they need.

Creative Peptides’s PNA FISH probe products enjoy many advantages. On the one hand, PNA probes possess a powerful specific hybridization capability since the PNA probe can avoid the hybridization instability caused by mutual charge repulsion when oligonucleotides bind to their target genes and is stable over the hybridization solution due to its non-chiral uncharged molecule. On the other hand, the high specificity of PNA by excellent oligonucleotide substituent enables rapid hybridization with just a small amount of PNA probe without significant background signal, resulting in a high signal-to-noise ratio and washing under mild conditions.

“Creative Peptides has been engaged in PNA for decades and developed a series of PNA products and services for customers. The PNA FISH probes have been rigorously validated and examined to enable high sensitivity.” The marketing director stated, “In addition to probes, Peptides also provides PNA reagents, PNA inhibitors, as well as golden-standard services related to PNA.”

About Creative Peptides

For decades, Creative Peptides has been the leader in peptide nucleic acid research in the United States. Peptides at current can serve a full range of high-quality products and comprehensive services in a wide range of markets including PNA design, PNA-based biochemical services, custom synthesis, chemical modification, and drug development services.