BioIVT to Discuss In Vitro Hepatic Models for Toxicity Studies at the AAPS Joint Workshop on Drug Transporters in ADME
WESTBURY, NY - Apr 16, 2018 - BioIVT, a leading provider of biospecimens and related services, today announced that it will be participating in two sessions at the American Association of Pharmaceutical Scientists (AAPS) Joint Workshop on Drug Transporters in ADME: From The Bench To The Bedside. This event will be held from Apr. 16-18 at the Hyatt Regency Dulles in Herndon, VA.
As drugs become more complex, there is an ongoing need for in vitro hepatic model systems that are as close as possible to a facsimile of the in vivo system to facilitate optimal toxicology studies, said Kenneth Brouwer, PhD, RPh, Vice President, ADME-Tox, at BioIVT.
BioIVT works hard to ensure that our product portfolio continues to evolve to meet industry needs. For example, we are now offering HEPATOPAC® kits, which are micropatterned co-culture liver models for both short and long-term ADME, toxicology and efficacy studies. We added those kits to our portfolio in March with our acquisition of Ascendance Biotechnology, Inc.
BioIVT will be presenting during the following sessions:
Monday, Apr. 16
12:15 - 12:45 pm
Presentation - Organic Solute Transporter OSTα/β: An Overlooked Transporter in Drug-Bile Acid Interactions
Presenters - Dr. Brouwer and Melina Malinen, PhD, MSc Pharm, UNC Eshelman School of Pharmacy
This session will cover basolateral efflux transporter function and regulation in different disease states. Drs. Brouwer and Malinen will discuss whether organic solute transporters should be considered in drug development.
1:00 - 1:30 pm and 6:30 - 7:00 pm
Poster P116 - C-DILI Assay: Integrating BSEP Inhibition and FXR Antagonism to Improve Prediction of Cholestatic Drug-Induced Liver Injury
Presenter - Dr. Brouwer
Attendees will be able to learn more about BioIVTs suite of liver-derived products, including its TRANSPORTER CERTIFIEDTM hepatocytes, and LIVERPOOL® cryoplateable, and cryosuspension human hepatocytes in booth #7. Its HEPATOPAC kits will also be offered. In addition, BioIVT PHASEZERO® Research Services consultants will be available to answer technical questions.
For more information about this AAPS workshop, please visit https://www.aaps.org/education-and-research/workshops/transporters18.
About BioIVT
BioIVT, formerly BioreclamationIVT, is a leading global provider of high-quality biological specimens and value-added services. We specialize in control and disease-state samples including human and animal tissues, cell products, blood and other biofluids. Our unmatched portfolio of clinical specimens directly supports precision medicine research and the effort to improve patient outcomes by coupling comprehensive clinical data with donor samples. Our PHASEZERO® Research Services team works collaboratively with clients to provide target and biomarker validation, phenotypic assays to characterize novel therapeutics, clinical assay development and in vitro hepatic modeling solutions. And as the premier supplier of ADME-toxicology model systems, including hepatocytes and subcellular fractions, BioIVT enables scientists to better understand the pharmacokinetics and drug metabolism of newly-discovered compounds and their effects on disease processes. By combining our technical expertise, exceptional customer service, and unparalleled access to biological specimens, BioIVT serves the research community as a trusted partner in elevating science. For more information, please visit www.bioivt.com or follow the company on Twitter @BioIVT.