• New Zinc-Finger Technology Makes For Faster, Better Genetic Editing

    Bio-IT World | CRISPR-based approaches that rely on the enzyme Cas9 to cut DNA at precise locations has been the darling of genetics research over the past few years. The revolutionary gene-editing system can also produce a lot of off-target activity. And when delivered via adeno-associated virus vectors, Cas9 occupies so much space that little room is left for any other therapeutic cargo that might be needed.

    Feb 14, 2023

  • Bioassays Have An Integration Problem: Collaboration Will Be Key To Making Them FAIR

    Bio-IT World | Whilst life science companies have come to recognize data as their greatest asset, it is also their greatest challenge. Much of data is siloed in different formats and locations, making it difficult to discover, query, and share—rendering data essentially unusable. FAIR data must be rolled out across the entire industry if companies want to accelerate R&D and enable scientific queries to be answered more rapidly.

    Feb 10, 2023

  • Biomedical Research Experts Reach Consensus on Open Science Practices to Monitor Institutions Worldwide

    Bio-IT World | A group of 80 research stakeholders convened to determine the best biomedical open science practices and create a fully automated dashboard to monitor their implementation. The team’s efforts will be used to improve research quality and foster innovation in the biomedical space.

    Feb 9, 2023

  • Deepcell Releases Sample Datasets to Highlight Morphology-Driven Data

    Bio-IT World | Deepcell, a pioneer in AI-powered single cell analysis to fuel deep biological discoveries, has released three datasets, available online, to enable researchers to explore novel high-dimensional morphology data. The datasets were generated on Deepcell’s high-throughput platform, comprised of imaging and sorting instrumentation, AI models, and a software suite.

    Feb 7, 2023

  • The Carbon Footprint Impact of Cloud Solutions

    Bio-IT World | While those in the life sciences appreciate the importance of curbing greenhouse gas emissions and the pressing impact of global warming, actionable steps toward going green have yet to permeate all facets of cloud computing research. As such, the current state of affairs in bioinformatic computing is not particularly green.

    Feb 3, 2023

  • 3D Spatial Proteomics Provides View Of Diseases At Early Stages

    Bio-IT World | Researchers in Germany have developed a series of innovative solutions for probing the body more broadly and deeply for early pathological signs of diseases ranging from metabolic disorders and neurodegenerative diseases to cancer. Their novel technology, dubbed DISCO-MS, does spatial proteomics in three-dimensional (3D) intact specimens using a combination of whole-organ and whole-organism clearing and imaging, deep-learning-based image analysis, robotic tissue extraction, and ultrahigh-sensitivity mass spectrometry.

    Feb 2, 2023

  • Retinal Organoid-Derived Neurons to Potentially Cure Degenerative Eye Disease

    Bio-IT World | A new study published in the Proceedings of the National Academy of Science demonstrates the potential for lab-grown retinal neurons to reestablish synaptic function and cure neurodegenerative eye disease, according to researchers from the University of Wisconsin–Madison.

    Jan 31, 2023

  • Take the DNA Delorean: The Promise of Large Language Models in Genomics

    Bio-IT World | Information directly from DNA to understand RNA's and human proteins' downstream structure describes how our cells function in clear linguistic terms. Today, large language models demonstrate remarkable abilities to interpret, translate, summarize, and generate human languages. Now, we are finally generating the amount of data required to train such models in the language of biology.

    Jan 27, 2023

  • Microsoft Applies AI to Digitial Cancer Pathology Imaging, World’s First Next-Generation Single-Molecule Protein Sequencing Platform, More

    Bio-IT World | A Salmonella-based bactofection platform to deliver RNA payloads to treat cancer patients; tRNA therapeutics capable of overcoming genetic errors to treat genetic diseases and cancer; the Jackson Laboratory enters an expansive and exclusive intellectual property licensing agreement across six areas of human health; and more.

    Jan 26, 2023

  • How Recursion Hopes to Harness the Big Picture View to Understand Biology’s Landscape

    Bio-IT World | In the latest episode of Trends from the Trenches podcast, host Stan Gloss of BioTeam sits down with Chris Gibson, co-founder and CEO of Recursion, to talk about Recursion’s mission to decode biology, radically improve lives, and set big goals to innovate across every stage of drug discovery.

    Jan 24, 2023

  • Follow the Money: University of Chicago Funds Biotech Accelerator, Breakthrough Tankless Inhaled Nitric Oxide Delivery System, More

    Bio-IT World | Funding for new therapeutic targets for a proprietary genetic medicines pipeline fueled by an automated discovery engine and versatile gene-editing toolbox, an in vivo engineered cell therapy platform for immuno-oncology genomic medicines, advanced therapeutic nucleic acids manufacturing, and more.

    Jan 24, 2023

  • NVIDIA Highlights AI, Large Language Model Advances in Life Sciences

    Bio-IT World | NVIDIA is the only semiconductor manufacturer to ever present at the J.P. Morgan Healthcare Conference, said Harlan Sur, the firm’s semiconductor analyst in his introduction of Kimberly Powell, NVIDIA’s VP of healthcare. This year—NVIDIA’s fourth year presenting at the conference—Powell emphasized why NVIDIA is a crucial part of the healthcare ecosystem.

    Jan 20, 2023

  • Digestion Speed The Latest Clue In Quest Against Obesity

    Bio-IT World | The time it takes food to travel from the mouth to the rectum may change the metabolism of microbes in the gut. That’s one of the intriguing possibilities raised by a stool energy density study on overweight Danes recently completed by researchers at the University of Copenhagen, reports Henrik Roager, associate professor in the department of nutrition, exercise and sports.

    Jan 19, 2023

  • Global Federated Machine Learning Model Detects Glioblastoma Borders

    Bio-IT World | In a paper published late last year in Nature Communications, researchers from Penn Medicine and Intel Labs report on what they call the largest to-date global federated learning effort to develop an accurate and generalizable machine learning model for detecting glioblastoma borders. The work has important implications both clinically and as a model for future large, federated learning projects.

    Jan 17, 2023

  • At J.P. Morgan, PacBio Updates on Impending Revio, Onso Shipments

    Bio-IT World | In his second J.P. Morgan Healthcare Conference address on behalf of Pacific Biosystems, CEO Christian Henry gave a summary of 2022 numbers and updates on the new sequencing platforms the company announced in October: the Revio long-read platform and the Onso short-read platform.

    Jan 13, 2023

  • Why Tech Transfer Needs a New Blueprint

    Bio-IT World | In BioPharma, development to manufacturing often feel as if they are separated by an invisible wall. While the enterprise may be joint, development and manufacturing cultures are distinct. Poor information sharing can make findings feel like closely guarded secrets. This siloed approach was the accepted norm in earlier eras. Now, it is due for a major renovation.

    Jan 13, 2023

  • At J.P. Morgan Illumina Reports Record-Breaking Uptake of NovaSeq X, Expanding Sequencing Market

    Bio-IT World | Illumina President and CEO Francis deSouza kicked off his annual J.P. Morgan Healthcare Conference presentation highlighting the breadth of the genomics market. deSouza sees a $120 billion total addressable market for Illumina, with oncology testing representing more than half of the opportunity.

    Jan 12, 2023

  • Three Pillars of 10x: Outlook for Single Cell, Spatial and In Situ Platforms

    Bio-IT World | Serge Saxonov, CEO and co-founder of 10x Genomics, kicked off Monday’s sessions at the 41st annual J.P. Morgan Healthcare Conference with an overview of the company’s overall progress in its Visium, Chromium, and Xenium platforms. Instead of delving too deeply in specific product announcements, Saxonov emphasized the strength of the 10x team, the mergers and acquisitions that have led to the development of the platforms, and the breadth of the company offerings.

    Jan 11, 2023

  • Genetic Engineering Breaks Ground In War Against Cancer

    Bio-IT World | Multiyear efforts using genetic engineering to study cancer development and interactions with components of the anti-tumor immune response were the subject of the Ernst W. Bertner Memorial Award keynote address delivered at the recent Leading Edge of Cancer Research Symposium of the University of Texas MD Anderson Cancer Center. The focus was on genetically engineered mouse models established to understand how cancer develops over time and to inform new approaches for both earlier detection and better treatment.

    Jan 10, 2023

  • Trendspotting: What’s Coming for Bio-IT in 2023

    Bio-IT World | We spoke with several leaders in the Bio-IT World community to gain insights about their predictions for the coming year. They anticipate increased use of AI and large language models for industry breakthroughs, significant data curation and computing advancements, widespread cost streamlining, and valiant efforts in pushing the boundaries of whole-genome studies.

    Jan 5, 2023